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Nevertheless, sulphasalazine has been demonstrated to be an effective treatment in cancer models, by inhibiting xCT to activate ferroptosis 232,233 and restore sensitivity to chemotherapy

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The above genome-wide studies did not detect any profound methylation of NeuroD1 and NeuroD2 in ESC-derived glutamatergic neurons, the brain tissue and various non-neural differentiated cells (Meissner et al., 2008